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劇情：倫納德（由約翰尼·加萊茨基飾演）和謝爾頓（由吉姆·帕森斯飾演）是一對智商超過360的瘋狂科學家宅男。他們的科學家朋友還包括濫交的Wolowitz（由Simon Helberg飾演）和從不與女性交談的印度人。最近，一位美麗的劇作家和餐廳老板Penny（Kaley Cuoco飾）從科學家御宅族的對面搬了進來。宅男開始坐立不安，幾個朋友之間爆發出許多有趣的故事。展開 
